Welcome to vnonline.co.uk

vnonline.co.uk provides the veterinary nursing profession with the latest news and industry developments, as well as events, resources, learning materials and careers.

Our website is dedicated to veterinary nurses and we strive to provide a platform where you can voice and explore your interests.

Not a member yet? Sign up for free!

Register for free with vnonline.co.uk to gain unlimited access to news, resources, jobs and much more!



Click here to become a member






Log in to vnonline

Forgot your password?

Posted: 22nd December 2017

New DNA test for cerebellar ataxia
CA is a serious neurological disease that causes the cerebellum - the part of the brain responsible for co-ordinating motor movement - to become diseased.
Italian Spinoni breeders encouraged to utilise linkage test 

An official new DNA testing programme for cerebellar ataxia (CA) in Italian Spinoni has been approved by the Kennel Club.

CA is a serious neurological disease that causes the cerebellum - the part of the brain responsible for co-ordinating motor movement - to become diseased.

The new ‘linkage’ test relies on the link between the disease-causing gene and the nearby genes. By contrast, most DNA tests identify the particular genetic mutation that is known to cause the disease.

Sometimes, however, determining the mutation can be difficult. It is possible to infer the disease-causing variant - and therefore whether the animal is animal clear, a carrier, or affected by the disease - from the ‘linked’ variants nearby. Variants at genes near one another on the same chromosome are usually inherited together (i.e. linked).

Linkage tests are not as accurate as those where the actual causal variant is known. However, the Kennel Clubs says these tests can still be highly accurate and, therefore, predictive.

“Cerebellar ataxia is a very distressing, progressive condition,” said Kennel Club Secretary Caroline Kisko. “While this DNA testing programme for the condition is different to the DNA tests so far recorded by the Kennel Club, the programme could enable breeders to make sensible breeding decisions to eradicate this condition in Italian Spinoni so we would recommend utilising it to ensure a healthier future for this lovely breed.”

Health conditions with a linkage test will be either autumnal dominant or autosomal recessive. The breeding advice remains to same as for conditions with these modes of inheritance, though breeders should be aware that linkage tests are not always 100 per cent accurate. As a result the Kennel Club will not assign progeny as ‘hereditarily clear’. Results will only be recorded for individual dogs.



Become a member or log in to add this story to your CPD history



Latest news | Careers | Events | Resources | Contact us | Terms and conditions | Data Protection and Privacy |Cookie policy | About us | Copyright
© 2024 Vision Media, all rights reserved. vnonline.co.uk is not responsible for the content of external websites.